A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation.

ABSTRACT: Single-cell RNA sequencing of embryos can resolve the transcriptional landscape of development at unprecedented resolution. To date, single-cell RNA-sequencing studies of mammalian embryos have focused exclusively on eutherian species. Analysis of mammalian outgroups has the potential to identify deeply conserved lineage specification and pluripotency factors, and can extend our understanding of X dosage compensation. Metatherian (marsupial) mammals diverged from eutherians around 160 million years ago. They exhibit distinctive developmental features, including late implantation¹ and imprinted X chromosome inactivation², which is associated with expression of the XIST-like noncoding RNA RSX³. Here we perform a single-cell RNA-sequencing analysis of embryoge

SUBMITTER: Mahadevaiah SK 

PROVIDER: S-EPMC7116401 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature