Motor training modulates intracortical inhibitory dynamics in motor cortex during movement preparation.

ABSTRACT:

Background

The primary motor cortex (M1) has a vital role to play in the learning of novel motor skills. However, the physiological changes underpinning this learning, particularly in terms of dynamic changes during movement preparation, are incompletely understood. In particular, a substantial decrease in resting gamma-amino butyric acid (GABA) activity, i.e. a release of resting inhibition, is seen within M1 as a subject prepares to move. Although there is evidence that a decrease in resting inhibition occurs within M1 during motor learning it is not known whether the pre-movement "release" of GABAergic inhibition is modulated during skill acquisition.

Objective

Here, we investigated changes in pre-movement GABAergic inhibitory "release" during training on a motor skill ta

SUBMITTER: Dupont-Hadwen J 

PROVIDER: S-EPMC7116431 | biostudies-literature | 2019 Mar - Apr

REPOSITORIES: biostudies-literature