Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease.

ABSTRACT: The disruption of pathologically enhanced beta oscillations is considered one of the key mechanisms mediating the clinical effects of deep brain stimulation on motor symptoms in Parkinson's disease. However, a specific modulation of other distinct physiological or pathological oscillatory activities could also play an important role in symptom control and motor function recovery during deep brain stimulation. Finely tuned gamma oscillations have been suggested to be prokinetic in nature, facilitating the preferential processing of physiological neural activity. In this study, we postulate that clinically effective high-frequency stimulation of the subthalamic nucleus imposes cross-frequency interactions with gamma oscillations in a cortico-subcortical network of interconnected regions and

SUBMITTER: Muthuraman M 

PROVIDER: S-EPMC7116448 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature