Brain micro-architecture and disinhibition: a latent phenotyping study across 33 impulsive and compulsive behaviours.

ABSTRACT: Impulsive and compulsive symptoms are common, tend to co-occur, and collectively account for a substantive global disease burden. Latent phenotyping offers a promising approach to elucidate common neural mechanisms conferring vulnerability to such symptoms in the general population. We utilised the Neuroscience in Psychiatry Network (NSPN), a cohort of young people (aged 18-29 years) in the United Kingdom, who provided questionnaire data and Magnetic Resonance Imaging scans. Partial Least Squares was used to identify brain regions in which intra-cortical myelination (measured using Magnetisation Transfer, MT) was significantly associated with a disinhibition phenotype, derived from bi-factor modelling of 33 impulsive and compulsive problem behaviours. The neuroimaging sample comprised 126

SUBMITTER: Romero-Garcia R 

PROVIDER: S-EPMC7116462 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature