International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function.

ABSTRACT: The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, γ-glutamyl peptides, polyamines, polycationic peptides, and protons. The CaSR plays a critical role in extracellular calcium (Ca²⁺ _o) homeostasis, as demonstrated by the many naturally occurring mutations in the CaSR or its signaling partners that cause Ca²⁺ _o homeostasis disorders. However, CaSR tissue expression in mammals is broad and includes tissues unrelated to Ca²⁺ _o homeostasis, in which it, for example, regulates the secretion of digestive hormones, airway constriction, cardiovascular effects, cellular diff

SUBMITTER: Leach K 

PROVIDER: S-EPMC7116503 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature