Biofilm interfacial acidity evaluation by pH-Responsive luminescent nanoparticle films.

ABSTRACT: Biofilms are dense bacterial colonies that may adhere to the surfaces of medical devices and are major contributors to infections. These colonies are characterized by a self-produced matrix of extracellular polymeric substances (EPS). Bacterial biofilms are difficult to treat with the commonly used antibiotics partially because of their poor diffusion through the EPS and therefore require new targeted strategies to effectively fight them. Biofilms may produce an acidic microenvironment which can be exploited to design such targeted treatment strategies. However, there is currently a lack of high-throughput ways to determine the acidity of biofilms at their interface with the medical device. Here, a novel all-inorganic pH responsive system is developed from luminescent carbonated hydroxyapa

SUBMITTER: Merkl P 

PROVIDER: S-EPMC7116521 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature