Ontology highlight
ABSTRACT:
SUBMITTER: Meran L
PROVIDER: S-EPMC7116539 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Meran Laween L Massie Isobel I Campinoti Sara S Weston Anne E AE Gaifulina Riana R Tullie Lucinda L Faull Peter P Orford Michael M Kucharska Anna A Baulies Anna A Novellasdemunt Laura L Angelis Nikolaos N Hirst Elizabeth E König Julia J Tedeschi Alfonso Maria AM Pellegata Alessandro Filippo AF Eli Susanna S Snijders Ambrosius P AP Collinson Lucy L Thapar Nikhil N Thomas Geraint M H GMH Eaton Simon S Bonfanti Paola P De Coppi Paolo P Li Vivian S W VSW
Nature medicine 20200907 10
Intestinal failure, following extensive anatomical or functional loss of small intestine, has debilitating long-term consequences for children<sup>1</sup>. The priority of patient care is to increase the length of functional intestine, particularly the jejunum, to promote nutritional independence<sup>2</sup>. Here we construct autologous jejunal mucosal grafts using biomaterials from pediatric patients and show that patient-derived organoids can be expanded efficiently in vitro. In parallel, we ...[more]