Initiation of a conserved trophectoderm program in human, cow and mouse embryos.

ABSTRACT: Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) placental progenitor program. The inner cell mass arises from inner cells during subsequent developmental stages and comprises precursor cells of the embryo proper and yolk sac¹. Recent gene-expression analyses suggest that the mechanisms that regulate early lineage specification in the mouse may differ in other mammals, including human^2-5 and cow⁶. Here we show the evolutionary conservation of a molecular cascade that initiates TE segregation in human, cow and mouse embryos. At the morula stage, outer cells acquire

SUBMITTER: Gerri C 

PROVIDER: S-EPMC7116563 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature