Ontology highlight
ABSTRACT:
SUBMITTER: Gerri C
PROVIDER: S-EPMC7116563 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gerri Claudia C McCarthy Afshan A Alanis-Lobato Gregorio G Demtschenko Andrej A Bruneau Alexandre A Loubersac Sophie S Fogarty Norah M E NME Hampshire Daniel D Elder Kay K Snell Phil P Christie Leila L David Laurent L Van de Velde Hilde H Fouladi-Nashta Ali A AA Niakan Kathy K KK
Nature 20200923 7834
Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) placental progenitor program. The inner cell mass arises from inner cells during subsequent developmental stages and comprises precursor cells of the embryo proper and yolk sac<sup>1</sup>. Recent gene-expression analyses suggest that the mechanisms that ...[more]