Human blood vessel organoids as a model of diabetic vasculopathy.

ABSTRACT: The increasing prevalence of diabetes has resulted in a global epidemic¹. Diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and amputation of lower limbs. These are often caused by changes in blood vessels, such as the expansion of the basement membrane and a loss of vascular cells^2-4. Diabetes also impairs the functions of endothelial cells⁵ and disturbs the communication between endothelial cells and pericytes⁶. How dysfunction of endothelial cells and/or pericytes leads to diabetic vasculopathy remains largely unknown. Here we report the development of self-organizing three-dimensional human blood vessel organoids from pluripotent stem cells. These human blood vessel organoids contain endothelial cells and pericytes

SUBMITTER: Wimmer RA 

PROVIDER: S-EPMC7116578 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature