Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study.

ABSTRACT:

Background

The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of survival in progressive supranuclear palsy (PSP).

Methods

In stage one of this two stage genome-wide association study (GWAS), we included individuals with PSP, diagnosed according to pathological and clinical criteria, from two separate cohorts: the 2011 PSP GWAS cohort, from brain banks based at the Mayo Clinic (Jacksonville, FL, USA) and in Munich (Germany), and the University College London PSP cohort, from brain banks and the PROSPECT study, a UK-wide longitudinal study of patients with atypical parkinsonian syndromes. Individuals were included if they had clinical data available on sex, age at motor symptom onset, dis

SUBMITTER: Jabbari E 

PROVIDER: S-EPMC7116626 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature