Retinal Vascular Tortuosity and Diameter Associations with Adiposity and Components of Body Composition.

ABSTRACT:

Objective

The aim of this study was to assess whether adiposity or body composition relates to microvascular characteristics of the retina, indicative of cardiometabolic function.

Methods

A fully automated QUARTZ software processed retinal images from 68,550 UK Biobank participants (aged 40-69 years). Differences in retinal vessel diameter and tortuosity with body composition measures from the Tanita analyzer were obtained by using multilevel regression analyses adjusted for age, sex, ethnicity, clinic, smoking, and Townsend deprivation index.

Results

Venular tortuosity and diameter increased by approximately 2% (P < 10^-300 ) and 0.6 μm (P < 10^-6 ), respectively, per SD increase in BMI, waist circumference index, waist-hip ratio, total body fat m

SUBMITTER: Tapp RJ 

PROVIDER: S-EPMC7116641 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature