Arterialization requires the timely suppression of cell growth.

ABSTRACT: The formation of arteries is thought to occur by the induction of a highly conserved arterial genetic programme in a subset of vessels that will later experience an increase in oxygenated blood flow^1,2. The initial steps of arterial specification require both the VEGF and Notch signalling pathways^3-5. Here, we combine inducible genetic mosaics and transcriptomics to modulate and define the function of these signalling pathways in cell proliferation, arteriovenous differentiation and mobilization. We show that endothelial cells with high levels of VEGF or Notch signalling are intrinsically biased to mobilize and form arteries; however, they are not genetically pre-determined, and can also form veins. Mechanistically, we found that increased levels of VEGF and Notch sig

SUBMITTER: Luo W 

PROVIDER: S-EPMC7116692 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature