A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T_reg cells.

ABSTRACT: Genetic variations underlying susceptibility to complex autoimmune and allergic diseases are concentrated within noncoding regulatory elements termed enhancers¹. The functions of a large majority of disease-associated enhancers are unknown, in part owing to their distance from the genes they regulate, a lack of understanding of the cell types in which they operate, and our inability to recapitulate the biology of immune diseases in vitro. Here, using shared synteny to guide loss-of-function analysis of homologues of human enhancers in mice, we show that the prominent autoimmune and allergic disease risk locus at chromosome 11q13.5^2-7 contains a distal enhancer that is functional in CD4⁺ regulatory T (T_reg) cells and required for T_reg-m

SUBMITTER: Nasrallah R 

PROVIDER: S-EPMC7116706 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature