Vascular targeted photodynamic therapy: A review of the efforts towards molecular targeting of tumor vasculature.

ABSTRACT: The therapeutic value of vascular targeted photodynamic therapy (VTP) for cancer has already been recognized in the clinic: TOOKAD^® has been clinically approved in Europe and Israel for treatment of men with low-risk prostate cancer. When light is applied shortly after intravenous administration of the photosensitizer, the damage is primarily done to the vasculature. This results in vessel constriction, blood flow stasis, and thrombus formation. Subsequently, the tumor is killed due to oxygen and nutrient deprivation. To further increase treatment specificity and to reduce undesired side effects such as damaging to the surrounding healthy tissues, efforts have been made to selectively target the PS to the tumor vasculature, an approach named molecular targeted VTP (molVTP). Seve

SUBMITTER: Mashayekhi V 

PROVIDER: S-EPMC7116708 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature