A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

ABSTRACT: Mitochondrial fidelity is tightly linked to overall cellular homeostasis and is compromised in ageing and various pathologies^1-3. Mitochondrial malfunction needs to be relayed to the cytosol, where an integrated stress response is triggered by the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) in mammalian cells^4,5. eIF2α phosphorylation is mediated by the four eIF2α kinases GCN2, HRI, PERK and PKR, which are activated by diverse types of cellular stress⁶. However, the machinery that communicates mitochondrial perturbation to the cytosol to trigger the integrated stress response remains unknown^1,2,7. Here we combine genome engineering and haploid genetics to unbiasedly identify genes that affect the induction of C/EBP homo

SUBMITTER: Fessler E 

PROVIDER: S-EPMC7116715 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature