Rescue of oxytocin response and social behaviour in a mouse model of autism.

ABSTRACT: A fundamental challenge in developing treatments for autism spectrum disorders is the heterogeneity of the condition. More than one hundred genetic mutations confer high risk for autism, with each individual mutation accounting for only a small fraction of cases^1-3. Subsets of risk genes can be grouped into functionally related pathways, most prominently those involving synaptic proteins, translational regulation, and chromatin modifications. To attempt to minimize this genetic complexity, recent therapeutic strategies have focused on the neuropeptides oxytocin and vasopressin^4-6, which regulate aspects of social behaviour in mammals⁷. However, it is unclear whether genetic risk factors predispose individuals to autism as a result of modifications to oxytoc

SUBMITTER: Hornberg H 

PROVIDER: S-EPMC7116741 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature