Ontology highlight
ABSTRACT:
SUBMITTER: Bottes S
PROVIDER: S-EPMC7116750 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Bottes Sara S Jaeger Baptiste N BN Pilz Gregor-Alexander GA Jörg David J DJ Cole John Darby JD Kruse Merit M Harris Lachlan L Korobeynyk Vladislav I VI Mallona Izaskun I Helmchen Fritjof F Guillemot François F Simons Benjamin D BD Jessberger Sebastian S
Nature neuroscience 20201221 2
Neural stem cells (NSCs) generate neurons throughout life in the mammalian hippocampus. However, the potential for long-term self-renewal of individual NSCs within the adult brain remains unclear. We used two-photon microscopy and followed NSCs that were genetically labeled through conditional recombination driven by the regulatory elements of the stem cell-expressed genes GLI family zinc finger 1 (Gli1) or achaete-scute homolog 1 (Ascl1). Through intravital imaging of NSCs and their progeny, we ...[more]