Host ANP32A mediates the assembly of the influenza virus replicase.

ABSTRACT: Aquatic birds represent a vast reservoir from which new pandemic influenza A viruses can emerge¹. Influenza viruses contain a negative-sense segmented RNA genome that is transcribed and replicated by the viral heterotrimeric RNA polymerase (FluPol) in the context of viral ribonucleoprotein complexes^2,3. RNA polymerases of avian influenza A viruses (FluPolA) replicate viral RNA inefficiently in human cells because of species-specific differences in acidic nuclear phosphoprotein 32 (ANP32), a family of essential host proteins for FluPol activity⁴. Host-adaptive mutations, particularly a glutamic-acid-to-lysine mutation at amino acid residue 627 (E627K) in the 627 domain of the PB2 subunit, enable avian FluPolA to overcome this restriction and efficiently repl

SUBMITTER: Carrique L 

PROVIDER: S-EPMC7116770 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature