Ca_v 1.3 channels play a crucial role in the formation of paroxysmal depolarization shifts in cultured hippocampal neurons.

ABSTRACT:

Objective

An increase of neuronal Ca_v 1.3 L-type calcium channels (LTCCs) has been observed in various animal models of epilepsy. However, LTCC inhibitors failed in clinical trials of epileptic treatment. There is compelling evidence that paroxysmal depolarization shifts (PDSs) involve Ca²⁺ influx through LTCCs. PDSs represent a hallmark of epileptiform activity. In recent years, a probable epileptogenic role for PDSs has been proposed. However, the implication of the two neuronal LTCC isoforms, Ca_v 1.2 and Ca_v 1.3, in PDSs remained unknown. Moreover, Ca²⁺ -dependent nonspecific cation (CAN) channels have also been suspected to contribute to PDSs. Nevertheless, direct experimental support of an important role of CAN channel act

SUBMITTER: Stiglbauer V 

PROVIDER: S-EPMC7116787 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature