Size at birth, growth trajectory in early life, and cardiovascular and metabolic risks in early adulthood: EPICure study.

ABSTRACT:

Objective

To investigate whether size at birth and growth trajectories in infancy and childhood are associated with determinants of cardiovascular and metabolic risks in young adults born extremely preterm (EP, <26 weeks of gestation).

Methods

We used longitudinal data from the EPICure study of 129 EP survivors up to 19 years in the UK and Ireland in 1995. Determinants of cardiovascular and metabolic risks at 19 years included the presence of metabolic syndrome, body mass index (BMI) and systolic blood pressure (SBP). Predictors were birth weight for gestation and gain in weight z-scores in the following periods: birth-postmenstrual age of 40 weeks (term), infancy (term-2.5 years), early childhood (2.5-6.0 years) and late childhood (6-11 years).

Results

Metabolic synd

SUBMITTER: Ni Y 

PROVIDER: S-EPMC7116791 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature