A general carbonyl alkylative amination for tertiary amine synthesis.

ABSTRACT: The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes^1,2 has stimulated efforts towards their streamlined synthesis^3-9. Arguably the most robust method for the synthesis of tertiary alkylamines is carbonyl reductive amination³, which comprises two elementary steps: the condensation of a secondary alkylamine with an aliphatic aldehyde to form an all-alkyl-iminium ion, which is subsequently reduced by a hydride reagent. Direct strategies have been sought for a 'higher order' variant of this reaction via the coupling of an alkyl fragment with an alkyl-iminium ion that is generated in situ^10-14. However, despite extensive efforts, the successful realization of a 'carbonyl

SUBMITTER: Kumar R 

PROVIDER: S-EPMC7116815 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature