Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides.

ABSTRACT: The nature of the first genetic polymer is the subject of major debate¹. Although the 'RNA world' theory suggests that RNA was the first replicable information carrier of the prebiotic era-that is, prior to the dawn of life^2,3-other evidence implies that life may have started with a heterogeneous nucleic acid genetic system that included both RNA and DNA⁴. Such a theory streamlines the eventual 'genetic takeover' of homogeneous DNA from RNA as the principal information-storage molecule, but requires a selective abiotic synthesis of both RNA and DNA building blocks in the same local primordial geochemical scenario. Here we demonstrate a high-yielding, completely stereo-, regio- and furanosyl-selective prebiotic synthesis of the purine deoxyribonucleosides: d

SUBMITTER: Xu J 

PROVIDER: S-EPMC7116818 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature