Ontology highlight
ABSTRACT:
SUBMITTER: Baumgartner ME
PROVIDER: S-EPMC7116823 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Baumgartner Michael E ME Dinan Michael P MP Langton Paul F PF Kucinski Iwo I Piddini Eugenia E
Nature cell biology 20210125 2
Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell competition, cells with a heterozygous mutation in ribosome genes, such as RpS3<sup>+/-</sup> cells, are eliminated by wild-type cells. How cells are primed as losers is partially understood and it has been proposed that reduced translation underpins the loser status of ribosome mutant, or Minute, cells. Here, using Drosophila, we show that reduced translation does not cause cell competition. Instea ...[more]