Proteotoxic stress is a driver of the loser status and cell competition.

ABSTRACT: Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell competition, cells with a heterozygous mutation in ribosome genes, such as RpS3^+/- cells, are eliminated by wild-type cells. How cells are primed as losers is partially understood and it has been proposed that reduced translation underpins the loser status of ribosome mutant, or Minute, cells. Here, using Drosophila, we show that reduced translation does not cause cell competition. Instead, we identify proteotoxic stress as the underlying cause of the loser status for Minute competition and competition induced by mahjong, an unrelated loser gene. RpS3^+/- cells exhibit reduced autophagic and proteasomal flux, accumulate protein aggregates and can be rescued from competitio

SUBMITTER: Baumgartner ME 

PROVIDER: S-EPMC7116823 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature