RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.

ABSTRACT: Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic thymus from shared T cell precursors, preceding the emergence of CD4⁺CD8⁺ (double-positive) T cells. Thymic ILC2 cells migrated to mucosal tissues, with colonization of the intestinal lamina propria. Expression of the transcription factor RORα repressed T cell development while promoting ILC2 development in the thymus. From RNA-seq, assay for transposase-accessible chromatin sequencing (ATAC-seq) and chromatin immunoprecipitation followed by sequencing (ChIP-seq) data, we propose a revised transcriptional circuit to explain the co-development of T cells and ILC2 cells from common progenit

SUBMITTER: Ferreira ACF 

PROVIDER: S-EPMC7116838 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature