Macrophage-derived glutamine boosts satellite cells and muscle regeneration.

ABSTRACT: Muscle regeneration is sustained by infiltrating macrophages and the consequent activation of satellite cells^1-4. Macrophages and satellite cells communicate in different ways^1-5, but their metabolic interplay has not been investigated. Here we show, in a mouse model, that muscle injuries and ageing are characterized by intra-tissue restrictions of glutamine. Low levels of glutamine endow macrophages with the metabolic ability to secrete glutamine via enhanced glutamine synthetase (GS) activity, at the expense of glutamine oxidation mediated by glutamate dehydrogenase 1 (GLUD1). Glud1-knockout macrophages display constitutively high GS activity, which prevents glutamine shortages. The uptake of macrophage-derived glutamine by satellite cells through the glutamine tran

SUBMITTER: Shang M 

PROVIDER: S-EPMC7116844 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature