Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.

ABSTRACT: Balanced fusion and fission are key for the proper function and physiology of mitochondria^1,2. Remodelling of the mitochondrial inner membrane is mediated by the dynamin-like protein mitochondrial genome maintenance 1 (Mgm1) in fungi or the related protein optic atrophy 1 (OPA1) in animals^3-5. Mgm1 is required for the preservation of mitochondrial DNA in yeast⁶, whereas mutations in the OPA1 gene in humans are a common cause of autosomal dominant optic atrophy-a genetic disorder that affects the optic nerve^7,8. Mgm1 and OPA1 are present in mitochondria as a membrane-integral long form and a short form that is soluble in the intermembrane space. Yeast strains that express temperature-sensitive mutants of Mgm1^9,10 or mammalian cells that

SUBMITTER: Faelber K 

PROVIDER: S-EPMC7116848 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature