Structural basis for RIFIN-mediated activation of LILRB1 in malaria.

ABSTRACT: The Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms occur when these parasites replicate in human blood. Despite the risk of immune detection, the parasite delivers proteins that bind to host receptors on the cell surfaces of infected erythrocytes. In the causative parasite of the most deadly form of malaria in humans, Plasmodium falciparum, RIFINs form the largest family of surface proteins displayed by erythrocytes¹. Some RIFINs can bind to inhibitory immune receptors, and these RIFINs act as targets for unusual antibodies that contain a LAIR1 ectodomain^2-4 or as ligands for LILRB1⁵. RIFINs stimulate the activation of and signalling by LILRB1⁵, which could potentially lead to the dampening of hum

SUBMITTER: Harrison TE 

PROVIDER: S-EPMC7116854 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature