Activation and disruption of a neural mechanism for novel choice in monkeys.

ABSTRACT: Neural mechanisms that mediate the ability to make value-guided decisions have received substantial attention in humans and animals^1-6. Experiments in animals typically involve long training periods. By contrast, choices in the real world often need to be made between new options spontaneously. It is therefore possible that the neural mechanisms targeted in animal studies differ from those required for new decisions, which are typical of human imaging studies. Here we show that the primate medial frontal cortex (MFC)⁷ is involved in making new inferential choices when the options have not been previously experienced. Macaques spontaneously inferred the values of new options via similarities with the component parts of previously encountered options. Functional magneti

SUBMITTER: Bongioanni A 

PROVIDER: S-EPMC7116896 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature