TRAF3 signaling: Competitive binding and evolvability of adaptive viral molecular mimicry.

ABSTRACT:

Background

The tumor necrosis factor receptor (TNFR) associated factor 3 (TRAF3) is a key node in innate and adaptive immune signaling pathways. TRAF3 negatively regulates the activation of the canonical and non-canonical NF-κB pathways and is one of the key proteins in antiviral immunity.

Scope of review

Here we provide a structural overview of TRAF3 signaling in terms of its competitive binding and consequences to the cellular network. For completion, we also include molecular mimicry of TRAF3 physiological partners by some viral proteins.

Major conclusions

By out-competing host partners, viral proteins aim to subvert TRAF3 antiviral action. Mechanistically, dynamic, competitive binding by the organism's own proteins and same-site adaptive pathogen mimicry follow th

SUBMITTER: Guven-Maiorov E 

PROVIDER: S-EPMC7117012 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature