Histo-blood group glycans in the context of personalized medicine.

ABSTRACT:

Background

A subset of histo-blood group antigens including ABO and Lewis are oligosaccharide structures which may be conjugated to lipids or proteins. They are known to be important recognition motifs not only in the context of blood transfusions, but also in infection and cancer development.

Scope of review

Current knowledge on the molecular background and the implication of histo-blood group glycans in the prevention and therapy of infectious and non-communicable diseases, such as cancer and cardiovascular disease, is presented.

Major conclusions

Glycan-based histo-blood groups are associated with intestinal microbiota composition, the risk of various diseases as well as therapeutic success of, e.g., vaccination. Their potential as prebiotic or anti-microbial agent

SUBMITTER: Dotz V 

PROVIDER: S-EPMC7117023 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature