In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection.

ABSTRACT: Trichuris trichiura is a parasite that infects 500 million people worldwide, leading to colitis, growth retardation and Trichuris dysentery syndrome. There are no licensed vaccines available to prevent Trichuris infection and current treatments are of limited efficacy. Trichuris infections are linked to poverty, reducing children's educational performance and the economic productivity of adults. We employed a systematic, multi-stage process to identify a candidate vaccine against trichuriasis based on the incorporation of selected T-cell epitopes into virus-like particles. We conducted a systematic review to identify the most appropriate in silico prediction tools to predict histocompatibility complex class II (MHC-II) molecule T-cell epitopes. These tools were used to identify candidate M

SUBMITTER: Zawawi A 

PROVIDER: S-EPMC7117776 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature