Isolated Cyclic Loading During Adolescence Improves Tibial Bone Microstructure and Strength at Adulthood.

ABSTRACT: Bone is a unique living tissue, which responds to the mechanical stimuli regularly imposed on it. Adolescence facilitates a favorable condition for the skeleton that enables the exercise to positively influence bone architecture and overall strength. However, it is still dubious for how long the skeletal benefits gained in adolescence is preserved at adulthood. The current study aims to use a rat model to investigate the effects of in vivo low- (LI), medium- (MI), and high- (HI) intensity cyclic loadings applied during puberty on longitudinal bone development, morphometry, and biomechanics during adolescence as well as at adulthood. Forty-two young (4-week-old) male rats were randomized into control, sham, LI, MI, and HI groups. After a 5 day/week for 8 weeks cyclic loading regime a

SUBMITTER: Mustafy T 

PROVIDER: S-EPMC7117850 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature