Functional brain connectivity in a rodent seizure model of autistic-like behavior.

ABSTRACT:

Objective

There is increasing evidence that Autism Spectrum Disorder (ASD) is a disorder of functional connectivity with both human and rodent studies demonstrating alterations in connectivity. Here, we hypothesized that early-life seizures (ELS) in rats would interrupt normal brain connectivity and result in autistic-like behavior (ALB).

Methods

Following 50 seizures, adult rats were tested in the social interaction and social novelty tests and then underwent qualitative and quantitative intracranial electroencephalography (EEG) monitoring in the medial prefrontal cortex (PFC) and the hippocampal subfields, CA3 and CA1.

Results

Rats with ELS showed deficits in social interaction and novelty, and compared with control, rats had marked increases in coherence within the

SUBMITTER: Mouchati PR 

PROVIDER: S-EPMC7117868 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature