Peripheral blood metabolite profiles associated with new onset atrial fibrillation.

ABSTRACT:

Background

Peripheral blood metabolite profiles have yielded mechanistic insights into various cardiovascular disease states. We hypothesized that peripheral blood metabolite profiles would be associated with new onset atrial fibrillation (AF).

Methods and results

The study population comprised 1892 patients without AF at baseline, who, as part the MURDOCK Cardiovascular Disease Study molecular profiling cohort (n = 2023), had previously had determination of levels of 69 metabolites from frozen, fasting plasma specimens obtained during coronary angiography. We used Cox proportional hazards models to examine the association of 13 uncorrelated metabolite factors created from these data using principal components analysis (PCA) with new occurrences of AF during a median follow

SUBMITTER: Harskamp RE 

PROVIDER: S-EPMC7117874 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature