Staphylococcus aureus Virulence Affected by an Alternative Nisin A Resistance Mechanism.

ABSTRACT: Nisin A is a bacteriocin produced by Lactococcus lactis and is widely used as a food preservative. Staphylococcus aureus has the BraRS-VraDE system that provides resistance against low concentrations of nisin A. BraRS is a two-component system that induces the expression of the ABC transporter VraDE. Previously, we isolated a highly nisin A-resistant strain with increased VraDE expression due to a mutation in braRS In this study, we isolated S. aureus MW2 mutants with BraRS-VraDE-independent nisin A resistance. These mutants, designated SAN2 ( S.aureusnisin resistant) and SAN469, had a mutation in pmtR, which encodes a transcriptional regulator responsible for the expression of the pmtABCD operon. As a result, these muta

SUBMITTER: Kawada-Matsuo M 

PROVIDER: S-EPMC7117933 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature