Polygenic risk for schizophrenia, disordered eating behaviours and body mass index in adolescents.

ABSTRACT:

Background

Recent studies suggest psychotic and eating disorders can be comorbid and could have shared genetic liability. However, this comorbidity has been overlooked in the epidemiological literature.AimsTo test whether polygenic risk scores (PRS) for schizophrenia are associated with disordered eating behaviours and body mass index (BMI) in the general population.

Method

Using data from the Avon Longitudinal Study of Parents and Children and random-effects logistic and linear regression models, we investigated the association between PRS for schizophrenia and self-reported disordered eating behaviours (binge eating, purging, fasting and excessive exercise) and BMI at 14, 16 and 18 years.

Results

Of the 6920 children with available genetic data, 4473 (64.6%) and 506

SUBMITTER: Solmi F 

PROVIDER: S-EPMC7117956 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature