Clustering of comorbid conditions among women who carry an FMR1 premutation.

ABSTRACT:

Purpose

Emerging evidence indicates that women who carry an FMR1 premutation can experience complex health profiles beyond the two well-established premutation-associated disorders: fragile X-associated primary ovarian insufficiency (FXPOI, affects ~20-30% carriers) and fragile X-associated tremor-ataxia syndrome (FXTAS, affects ~6-15% carriers).

Methods

To better understand premutation-associated health profiles, we collected self-reported medical histories on 355 carrier women.

Results

Twenty-two health conditions were reported by at least 10% of women. Anxiety, depression, and headaches were reported by more than 30%. The number of comorbid conditions was significantly associated with body mass index (BMI) and history of smoking, but not age. Survival analysis indi

SUBMITTER: Allen EG 

PROVIDER: S-EPMC7118023 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature