Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data.

ABSTRACT:

Background

Early menopause is linked to an increased risk of cardiovascular disease mortality; however, the association between early menopause and incidence and timing of cardiovascular disease is unclear. We aimed to assess the associations between age at natural menopause and incidence and timing of cardiovascular disease.

Methods

We harmonised and pooled individual-level data from 15 observational studies done across five countries and regions (Australia, Scandinavia, the USA, Japan, and the UK) between 1946 and 2013. Women who had reported their menopause status, age at natural menopause (if postmenopausal), and cardiovascular disease status (including coronary heart disease and stroke) were included. We excluded women who had hysterectomy or oophorectomy and women who

SUBMITTER: Zhu D 

PROVIDER: S-EPMC7118366 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature