Molecular Targets for Combined Therapeutic Strategies to Limit Glioblastoma Cell Migration and Invasion.

ABSTRACT: The highly invasive nature of glioblastoma imposes poor prospects for patient survival. Molecular evidence indicates glioblastoma cells undergo an intriguing expansion of phenotypic properties to include neuron-like signaling using excitable membrane ion channels and synaptic proteins, augmenting survival and motility. Neurotransmitter receptors, membrane signaling, excitatory receptors, and Ca²⁺ responses are important candidates for the design of customized treatments for cancers within the heterogeneous central nervous system. Relatively few published studies of glioblastoma multiforme (GBM) have evaluated pharmacological agents targeted to signaling pathways in limiting cancer cell motility. Transcriptomic analyses here identified classes of ion channels, ionotropic receptor

SUBMITTER: Yool AJ 

PROVIDER: S-EPMC7118801 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature