A pan-cancer study of class-3 semaphorins as therapeutic targets in cancer.

ABSTRACT:

Background

Initially characterized as axon guidance factors, semaphorins also have been implicated to have critical roles in multiple physiological and developmental functions, including the regulation of immune responses, angiogenesis, organ formation, and the etiology of multiple forms of cancer. Moreover, their contribution in immunity and the regulation of tumour microenvironment is becoming increasingly recognized. Here, we provide a comprehensive analysis of class-3 semaphorins, the only secreted family of genes among veterbrate semaphorins, in terms of their expression profiles and their association with patient survival. We also relate their role with immune subtypes, tumour microenvironment, and drug sensitivity using a pan-cancer study.

Results

Expression profiles

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7118829 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature