M⁶A-dependent glycolysis enhances colorectal cancer progression.

ABSTRACT:

Background

Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N⁶-methyladenosine (m⁶A) modifications of RNAs are emerging as a new layer of epigenetic regulation. As the most abundant chemical modification of eukaryotic mRNA, m⁶A is essential for the regulation of mRNA stability, splicing, and translation. Alterations of m⁶A regulatory genes play important roles in the pathogenesis of a variety of human diseases. However, whether this mRNA modification participates in the glucose metabolism of colorectal cancer (CRC) remains uncharacterized.

Methods

Transcriptome-sequencing and liquid chromatography-tandem mass spectrometry (LC-MS) were performed to evaluate the correlation between m⁶A m

SUBMITTER: Shen C 

PROVIDER: S-EPMC7118901 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature