KLF4^K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment.

ABSTRACT: Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however, have largely remained elusive. Here we report that the Krueppel like factor 4 (KLF4)-K409Q mutation in skull base meningiomas triggers a distinct tumor phenotype. Transcriptomic analysis of 17 meningioma samples revealed that KLF4^K409Q mutated tumors harbor an upregulation of hypoxia dependent pathways. Detailed in vitro investigation further showed that the KLF4^K409Q mutation induces HIF-1α through the reduction of prolyl hydroxylase activity and causes an upregulation of downstr

SUBMITTER: von Spreckelsen N 

PROVIDER: S-EPMC7118946 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature