Comparison of serum protein profiles between major depressive disorder and bipolar disorder.

ABSTRACT:

Background

Major depressive disorder and bipolar disorder are prevalent and debilitating psychiatric disorders that are difficult to distinguish, as their diagnosis is based on behavioural observations and subjective symptoms. Quantitative protein profile analysis might help to objectively distinguish between these disorders and increase our understanding of their pathophysiology. Thus, this study was conducted to compare the peripheral protein profiles between the two disorders.

Methods

Serum samples were collected from 18 subjects with major depressive disorder and 15 subjects with bipolar disorder. After depleting abundant proteins, liquid chromatography-tandem mass spectrometry (LC-MS/MS) and label-free quantification were performed. Data-dependent acquisition data were

SUBMITTER: Rhee SJ 

PROVIDER: S-EPMC7118970 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature