Comprehensive chromosomal aberrations in a case of a patient with TCF3-HLF-positive BCP-ALL.

ABSTRACT:

Background

The use of high-throughput analytical techniques has enabled the description of acute lymphoblastic leukaemia (ALL) subtypes. The TCF3-HLF translocation is a very rare rearrangement in ALL that is associated with an extremely poor prognosis. The TCF3-HLF fusion gene in the described case resulted in the fusion of the homeobox-related gene of TCF3 to the leucine zipper domain of HLF. The TCF3-HLF fusion gene product acts as a transcriptional factor leading to the dedifferentiation of mature B lymphocytes into an immature state (lymphoid stem cells). This process initiates the formation of pre-leukaemic cells. Due to the rarity of this chromosomal aberration, only a few cases have been described in the literature. The advantage of this work is the presentation of an intere

SUBMITTER: Lejman M 

PROVIDER: S-EPMC7118981 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature