MI-MAAP: marker informativeness for multi-ancestry admixed populations.

ABSTRACT:

Background

Admixed populations arise when two or more previously isolated populations interbreed. A powerful approach to addressing the genetic complexity in admixed populations is to infer ancestry. Ancestry inference including the proportion of an individual's genome coming from each population and its ancestral origin along the chromosome of an admixed population requires the use of ancestry informative markers (AIMs) from reference ancestral populations. AIMs exhibit substantial differences in allele frequency between ancestral populations. Given the huge amount of human genetic variation data available from diverse populations, a computationally feasible and cost-effective approach is becoming increasingly important to extract or filter AIMs with the maximum information conten

SUBMITTER: Chen S 

PROVIDER: S-EPMC7119171 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature