Patterns of gene evolution following duplications and speciations in vertebrates.

ABSTRACT:

Background

Eukaryotic genes typically form independent evolutionary lineages through either speciation or gene duplication events. Generally, gene copies resulting from speciation events (orthologs) are expected to maintain similarity over time with regard to sequence, structure and function. After a duplication event, however, resulting gene copies (paralogs) may experience a broader set of possible fates, including partial (subfunctionalization) or complete loss of function, as well as gain of new function (neofunctionalization). This assumption, known as the Ortholog Conjecture, is prevalent throughout molecular biology and notably plays an important role in many functional annotation methods. Unfortunately, studies that explicitly compare evolutionary processes between speciati

SUBMITTER: David KT 

PROVIDER: S-EPMC7120047 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature