Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy.

ABSTRACT: Enthusiasm for cell therapy for myocardial injury has waned due to equivocal benefits in clinical trials. In an attempt to improve efficacy, we investigated repeated cell therapy and adjunct renal denervation (RDN) as strategies for augmenting cardioprotection with cardiosphere-derived cells (CDCs). We hypothesized that combining CDC post-conditioning with repeated CDC doses or delayed RDN therapy would result in superior function and remodeling. Wistar-Kyoto (WKY) rats or spontaneously hypertensive rats (SHR) were subjected to 45 min of coronary artery ligation followed by reperfusion for 12-14 weeks. In the first study arm, SHR were treated with CDCs (0.5 × 10⁶ i.c.) or PBS 20 min following reperfusion, or additionally treated with CDCs (1.0 × 10⁶ i.v.) at 2, 4, and

SUBMITTER: Polhemus DJ 

PROVIDER: S-EPMC7121860 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature