Recent metformin adherence and the risk of hypoglycaemia in the year following intensification with a sulfonylurea.

ABSTRACT:

Aim

To evaluate whether recent low adherence to metformin monotherapy is associated with hypoglycaemia after addition of a sulfonylurea.

Methods

We assembled a retrospective cohort of veterans who filled a new prescription for metformin between 2001 and 2011 and intensified treatment with a sulfonylurea after ≥1 year of metformin use. We calculated metformin adherence from pharmacy data using the proportion of days covered in the 180-day period before intensification. The primary outcome was hypoglycaemia, defined as a hospitalization or emergency department visit for hypoglycaemia or an outpatient blood glucose measurement <3.3 mmol/l in the year following intensification. Cox proportional hazards models were used to compare the risk of hypoglycaemia between participants wi

SUBMITTER: Min JY 

PROVIDER: S-EPMC7121933 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature