Differential DNA Methylation in Placenta Associated With Maternal Blood Pressure During Pregnancy.

ABSTRACT: Abnormal blood pressure during pregnancy is associated with impaired fetal growth, predisposing the offspring to cardiometabolic abnormalities over the life-course. Placental DNA methylation may be the regulatory pathway through which maternal blood pressure influences fetal and adult health outcomes. Epigenome-wide association study of 301 participants with placenta sample examined associations between DNA methylation and millimetre of mercury increases in systolic and diastolic blood pressure in each trimester. Findings were further examined using gene expression, gene pathway, and functional annotation analyses. Cytosine-(phosphate)-guanine (CpGs) known to be associated with cardiometabolic traits were evaluated. Increased maternal systolic and diastolic blood pressure were associated w

SUBMITTER: Workalemahu T 

PROVIDER: S-EPMC7122078 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature