Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC7122131 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Zhang Yanhong Y Feng Xiuli X Zhang Jin J Chen Minyi M Huang Eric E Chen Xinbin X
Oncogene 20190722 35
p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2). Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism. In this study, we found that FDXR deficiency decreased mutant p53 expression along with altered iron metabolism in p53<sup>R270H/-</sup> MEFs and cancer cells carrying mutant p53. Consistentl ...[more]